Bellamine for hot flashes: An effective nonhormonal treatment?

content provided by

Bellamine for hot flashes: An effective nonhormonal treatment?


My gynecologist just prescribed Bellamine to relieve my hot flashes. What can you tell me about the ingredients in this medication? Is it effective?



Bellamine is a prescription medication that is used to treat symptoms of menopause, such as hot flashes. It is a combination of:

  • Belladonna, an herb with antispasmodic properties
  • Ergotamine, a medication that narrows blood vessels (vasoconstrictor)
  • Phenobarbital, a barbiturate that reduces brain and nervous system activity

In two small clinical trials, the combination of belladonna, ergotamine and phenobarbital was found to be slightly more effective than a placebo in relieving hot flashes. But larger clinical trials are needed to support these initial findings.

Bellamine isn't usually recommended as a first-line drug to treat hot flashes because of its potential side effects, which can include sedation. For this reason, other medications — such as estrogens, selective serotonin reuptake inhibitors, gabapentin or clonidine — are often tried first before Bellamine.

Last Updated: 05/02/2007
© 1998-2016 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "," "Mayo Clinic Health Information," "Reliable information for a healthier life" and the triple-shield Mayo logo are trademarks of Mayo Foundation for Medical Education and Research.

Terms and conditions of use


Bookmark and Share   E-Mail Page   Printer Friendly Version